{"id":363773,"date":"2025-10-14T17:00:28","date_gmt":"2025-10-14T11:30:28","guid":{"rendered":"https:\/\/www.scconline.com\/blog\/?p=363773"},"modified":"2025-10-14T17:12:44","modified_gmt":"2025-10-14T11:42:44","slug":"advisory-issued-ban-on-coldrif-cough-syrup-esic-health-update","status":"publish","type":"post","link":"https:\/\/www.scconline.com\/blog\/post\/2025\/10\/14\/advisory-issued-ban-on-coldrif-cough-syrup-esic-health-update\/","title":{"rendered":"Why you shouldn&#8217;t Buy, Use, or Distribute Coldrif Cough Syrup &#8212; Read the Advisory"},"content":{"rendered":"<div style=\"text-align: justify; line-height: 150%;\">\n<p style=\"margin-bottom: 3%;\">In response to a tragic series of child deaths allegedly linked to consumption of <span style=\"font-weight: bold;\">Coldrif Cough Syrup<\/span>, the <span style=\"font-weight: bold;\">Ministry of Health and Family Welfare<\/span> announced a ban on the purchase, utilisation, and distribution of the <span style=\"font-weight: bold;\">Cough<\/span> <span style=\"font-weight: bold;\">Syrup<\/span>.<\/p>\n<h3>The Root Cause:<\/h3>\n<p style=\"margin-bottom: 3%;\">The Coldrif Cough Syrup crisis began in <span style=\"font-weight: bold;\">September 2025<\/span>, when health authorities in Madhya Pradesh reported the sudden <span style=\"font-weight: bold;\">deaths of 14 children<\/span>, all of whom had consumed Coldrif Cough Syrup manufactured by M\/s Sresan Pharmaceuticals, Puducherry.<\/p>\n<p style=\"margin-bottom: 3%;\">Laboratory tests revealed the presence of <span style=\"font-weight: bold;\">Diethylene Glycol<\/span>, a toxic industrial solvent known to cause kidney failure and death. The situation escalated when <span style=\"font-weight: bold;\">over 20 children died in Chhindwara, Madhya Pradesh<\/span>, under similar circumstances.<\/p>\n<p style=\"margin-bottom: 3%;\">As reported, in <span style=\"font-weight: bold;\">Rajasthan<\/span>, <span style=\"font-weight: bold;\">3 children died<\/span> due to consumption of this <span style=\"font-weight: bold;\">Cough Syrup<\/span> lending to the suspension of the Drug Controller and a halt on 19 medicines, intensifying nationwide scrutiny.<\/p>\n<p style=\"margin-bottom: 3%;\">In MP, a government paediatrician was subsequently <span style=\"font-weight: bold;\">arrested under Section <a href=\"https:\/\/www.scconline.com\/DocumentLink.aspx?q=JTXT-9001803440\" target=\"_blank\">105<\/a> and <a href=\"https:\/\/www.scconline.com\/DocumentLink.aspx?q=JTXT-9001803629\" target=\"_blank\">276<\/a> of the <a href=\"https:\/\/www.scconline.com\/DocumentLink.aspx?q=JTXT-9001804326\" target=\"_blank\">Bharatiya Nyaya Sanhita, 2023<\/a><\/span>, along with <span style=\"font-weight: bold;\">Section <a href=\"https:\/\/www.scconline.com\/DocumentLink.aspx?q=JTXT-0001541960\" target=\"_blank\">27-A<\/a> of the <a href=\"https:\/\/www.scconline.com\/DocumentLink.aspx?q=JTXT-0002852199\" target=\"_blank\">Drugs and Cosmetics Act, 1940<\/a><\/span>, for prescribing this syrup.<\/p>\n<p style=\"margin-bottom: 3%;\">The doctor stated that he was <span style=\"font-weight: bold;\">falsely implicated<\/span>, arguing that the syrup had been <span style=\"font-weight: bold;\">approved and recommended by the Central Drugs Standard Control Organization (&#8216;CDSCO&#8217;).<\/span><\/p>\n<p style=\"margin-bottom: 3%;\">The State emphasised that the ingredients in the prescribed syrup are harmful and instructed that such medications should not be administered to children under the <span style=\"font-weight: bold;\">age of 4<\/span>.<\/p>\n<p style=\"margin-bottom: 3%;\"><span style=\"font-weight: bold;\">Read more:<\/span> <a href=\"https:\/\/www.scconline.com\/blog\/post\/2025\/10\/13\/mp-cough-syrup-deaths-case-court-denies-bail-doctor-prescribed-cough-syrup\/\" target=\"_blank\">MP Cough Syrup Deaths Case | Madhya Pradesh District Court rejects bail application of doctor who prescribed toxic cough syrup.<\/a><\/p>\n<h3>The Advisory:<\/h3>\n<p style=\"margin-bottom: 3%;\">In a swift and decisive response to emerging health concerns, the <span style=\"font-weight: bold;\">Employees&#8217; State Insurance Corporation<\/span> (&#8216;ESIC&#8217;) has issued a nationwide advisory halting all activities related to Coldrif Cough Syrup.<\/p>\n<p>On <span style=\"font-weight: bold;\">3-10-2025<\/span>, ESIC issued guidance on the rational use of cough syrup in children. In the paediatric population, cough syrup usage is not recommended:<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>\n<p>Strictly under the <span style=\"font-weight: bold;\">age of 2 years<\/span><\/p>\n<\/li>\n<li>\n<p style=\"margin-bottom: 3%;\">Under careful evaluation below the <span style=\"font-weight: bold;\">age of 5 years<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"margin-bottom: 3%;\">It is advised that healthcare facilities and clinical establishments adhere to good manufacturing practices. States and Union Territories are instructed to <span style=\"font-weight: bold;\">implement the advisory<\/span> across all government dispensaries and hospitals.<\/p>\n<p style=\"margin-bottom: 3%;\">ESIC initiated an internal review and began coordinating with relevant health and regulatory authorities to assess the situation.<\/p>\n<p style=\"margin-bottom: 3%;\">On <span style=\"font-weight: bold;\">7-10-2025<\/span>, the Health Ministry emphasized the importance of rational drug use and patient safety, reiterating the need for judicious <span style=\"font-weight: bold;\">prescribing and dispensing of cough syrups<\/span> for children.<\/p>\n<p>It was directed to ensure:<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>\n<p>Circulation of Advisory<\/p>\n<\/li>\n<li>\n<p>Sensitise patients<\/p>\n<\/li>\n<li>\n<p style=\"margin-bottom: 3%;\">Educate Medical officers\/Nursing Officers<\/p>\n<\/li>\n<\/ul>\n<p style=\"margin-bottom: 3%;\">ESIC <span style=\"font-weight: bold;\">mandated compliance<\/span> and made Heads of Institutions responsible for implementing the advisory.<\/p>\n<p>On <span style=\"font-weight: bold;\">8-10-2025<\/span>, the ESIC issued the directions for strict compliance regarding:<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-weight: bold;\">Purchase, issuance, distribution, and utilisation<\/span> of Coldrif Cough Syrup is strictly prohibited.<\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: bold;\">Withdraw issued stock<\/span> without delay.<\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: bold;\">Return available stock<\/span> to the original procurement source.<\/p>\n<\/li>\n<li>\n<p style=\"margin-bottom: 3%;\"><span style=\"font-weight: bold;\">Submit compliance confirmation<\/span> to ESIC Headquarters promptly.<\/p>\n<\/li>\n<\/ul>\n<p style=\"margin-bottom: 3%;\">All ESIC-run and government affiliated institutions are required to comply with the directive immediately. Medical Superintendents, Store In-Charges, and Pharmacy Officers have to ensure that no further issuance or use of the syrup occurs and that all stock is properly accounted for and returned.<\/p>\n<p>The advisory underscores the importance of vigilant pharmacovigilance and rapid response to potential drug-related hazards. ESIC&#8217;s proactive measures reflect its commitment to patient safety and public health. Patients and caregivers are advised to:<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-weight: bold;\">Avoid consuming<\/span> Coldrif Cough Syrup.<\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: bold;\">Seek medical attention<\/span> if symptoms occur after its use.<\/p>\n<\/li>\n<li>\n<p style=\"margin-bottom: 3%;\"><span style=\"font-weight: bold;\">Report possession<\/span> or usage to the nearest health facility.<\/p>\n<\/li>\n<\/ul>\n<p>The WHO Alert:<\/p>\n<p style=\"margin-bottom: 3%;\">On 13-10-2025, the <span style=\"font-weight: bold;\">World Health Organisation<\/span> (&#8216;WHO&#8217;) issued a Medical Product Alert identifying three contaminated cough syrups, Coldrif, Respifresh TR, and ReLife<a id=\"fnref1\" href=\"#fn1\" title=\"1. n5_2025_syrup-medicines_en.pdf\"><sup>1<\/sup><\/a>, linked to child deaths in India. The syrups contained Diethylene Glycol, a toxic solvent causing acute kidney injury and fatalities. The products identified are considered <span style=\"font-weight: bold;\">substandard<\/span> as they fail to meet their quality standards.<\/p>\n<p style=\"margin-bottom: 3%;\">WHO urges health-care professionals to report substandard product detections and adverse effects and advises increased surveillance across formal and informal supply chains.<\/p>\n<\/div>\n<hr\/>\n<p style=\"margin-left: 18pt; text-indent: -18pt;\"><a id=\"fn1\" href=\"#fnref1\">1.<\/a> <a href=\"https:\/\/cdn.who.int\/media\/docs\/default-source\/substandard-and-falsified\/n5_2025_syrup-medicines_en.pdf?sfvrsn=652770c2_1\" target=\"_blank\">n5_2025_syrup-medicines_en.pdf<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p style=\"font-style: italic;\">Ministry of Health, ESIC and WHO have issued an advisory banning the purchase, use, and distribution of Coldrif Cough Syrup after child fatalities.<\/p>\n","protected":false},"author":67525,"featured_media":363779,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4,1193],"tags":[49088,90801,90842,84259,90841,40371,40336,90799,90843,40266],"class_list":["post-363773","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-legislationupdates","category-notifications","tag-cdsco","tag-coldrif-cough-syrup","tag-diethylene-glycol","tag-drug-ban","tag-esic-advisory","tag-health-care-professionals","tag-ministry-of-health","tag-mp-cough-syrup-deaths-case","tag-paediatric","tag-who"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.4 (Yoast SEO v26.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Coldrif Cough Syrup Ban: Nationwide Advisory Issued | SCC Times<\/title>\n<meta name=\"description\" content=\"An 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Cough Syrup Deaths Case| &#8220;Most shocking case in medical history&#8221;: MP HC denies relief to distributor who sold Coldrif cough syrup","author":"Sonali Ahuja","date":"December 3, 2025","format":false,"excerpt":"At the outset, the Court remarked that the subject case was one of the most shocking cases in the medical history where as many as 30 children died by alleged consumption of the Coldrif cold syrup.","rel":"","context":"In &quot;Case Briefs&quot;","block_context":{"text":"Case Briefs","link":"https:\/\/www.scconline.com\/blog\/post\/category\/casebriefs\/"},"img":{"alt_text":"Cough Syrup Deaths","src":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2025\/12\/Cough-Syrup-Deaths.webp?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2025\/12\/Cough-Syrup-Deaths.webp?resize=350%2C200&ssl=1 1x, 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Case","src":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2025\/10\/MP-Cough-Syrup-Deaths-Case.webp?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2025\/10\/MP-Cough-Syrup-Deaths-Case.webp?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2025\/10\/MP-Cough-Syrup-Deaths-Case.webp?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2025\/10\/MP-Cough-Syrup-Deaths-Case.webp?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":247628,"url":"https:\/\/www.scconline.com\/blog\/post\/2021\/04\/26\/vicarious-liability\/","url_meta":{"origin":363773,"position":2},"title":"J&#038;K HC | Death by consumption of spurious cough syrup; is government vicariously liable? HC backs up NHRC\u2019s order directing State to pay 3 lakh compensation","author":"Editor","date":"April 26, 2021","format":false,"excerpt":"Jammu and Kashmir High Court: The Division Bench of Pankaj Mithal, CJ. and Sindhu Sharma, J., upheld National Human Rights Commission\u2019s order regarding compensation, whereby the commission had held the government vicariously liable for the death of children in Udhampur district due to consumption of spurious cough syrup. The Bench\u2026","rel":"","context":"In &quot;Case Briefs&quot;","block_context":{"text":"Case Briefs","link":"https:\/\/www.scconline.com\/blog\/post\/category\/casebriefs\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":376225,"url":"https:\/\/www.scconline.com\/blog\/post\/2026\/02\/20\/mp-cough-syrup-deaths-case-mp-hc-denies-bail\/","url_meta":{"origin":363773,"position":3},"title":"MP Cough Syrup Deaths Case| MP HC denies bail to doctor, medical store owners, and pharmacists, notes forgery of bills and destruction of evidence","author":"Sonali Ahuja","date":"February 20, 2026","format":false,"excerpt":"The Court noted that the accused doctor received commission for prescribing the cough syrup and his co-accused destroyed the evidence regarding cough syrup to save him.","rel":"","context":"In &quot;Case Briefs&quot;","block_context":{"text":"Case Briefs","link":"https:\/\/www.scconline.com\/blog\/post\/category\/casebriefs\/"},"img":{"alt_text":"MP Cough Syrup Deaths","src":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2026\/02\/MP-Cough-Syrup-Deaths.webp?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2026\/02\/MP-Cough-Syrup-Deaths.webp?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2026\/02\/MP-Cough-Syrup-Deaths.webp?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2026\/02\/MP-Cough-Syrup-Deaths.webp?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":293498,"url":"https:\/\/www.scconline.com\/blog\/post\/2023\/05\/31\/dgft-revises-export-policy-for-cough-syrup-legal-news\/","url_meta":{"origin":363773,"position":4},"title":"DGFT mandates obtaining of Certificate of Analysis for Export of Cough Syrup","author":"Kriti","date":"May 31, 2023","format":false,"excerpt":"On 22-5-2023, the Directorate General of Foreign Trade tightens the Export Policy of Cough Syrup. The revised export policy of Cough Syrup under ITS (HS) Codes falling under the Heading 3004 will come into effect on 1-6-2023. Existing Export Policy: Free The Revised Export Policy: Cough Syrups can only be\u2026","rel":"","context":"In &quot;Legislation Updates&quot;","block_context":{"text":"Legislation Updates","link":"https:\/\/www.scconline.com\/blog\/post\/category\/legislationupdates\/"},"img":{"alt_text":"directorate general of foreign trade","src":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2023\/05\/directorate-general-of-foreign-trade.webp?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2023\/05\/directorate-general-of-foreign-trade.webp?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2023\/05\/directorate-general-of-foreign-trade.webp?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.scconline.com\/blog\/wp-content\/uploads\/2023\/05\/directorate-general-of-foreign-trade.webp?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":252441,"url":"https:\/\/www.scconline.com\/blog\/post\/2021\/08\/09\/possession-of-cough-syrup\/","url_meta":{"origin":363773,"position":5},"title":"MP HC | Possession of cough syrup or medicine containing Codeine Phosphate without valid documents falls under S. 37 of the NDPS Act; Court rejects bail application","author":"Editor","date":"August 9, 2021","format":false,"excerpt":"Madhya Pradesh High Court: Rajeev Kumar Dubey, J., denied bail to the applicant who was arrested for the offence punishable under Sections 8, 21, 22 of the NDPS Act & Section 5\/13 of M.P. Drug Control Act. The prosecution had submitted that on the information of informant police stopped motor\u2026","rel":"","context":"In &quot;Case Briefs&quot;","block_context":{"text":"Case Briefs","link":"https:\/\/www.scconline.com\/blog\/post\/category\/casebriefs\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/posts\/363773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/users\/67525"}],"replies":[{"embeddable":true,"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/comments?post=363773"}],"version-history":[{"count":0,"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/posts\/363773\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/media\/363779"}],"wp:attachment":[{"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/media?parent=363773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/categories?post=363773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.scconline.com\/blog\/wp-json\/wp\/v2\/tags?post=363773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}